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In these mutant mice, secretory cells’ expulsion of mucin was lowered by about 70%, and mucus-plaque development while in the airway was decreased by Nearly seventy five%, in contrast with wild-style mice. Synaptotagmin was Plainly a genuine therapeutic concentrate on.
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Get the job done by Other people, which includes Dickey, has proven that upsized mucin secretion inside the airways operates in Considerably the same way, involving analogous vesicles (full of mucin instead of neurotransmitters) and synaptotagmin and collaborating proteins.
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